cheap jerseys Wholesale Jerseys Wholesale Jerseys nfl jerseys china wholesale nfl jerseys cheap nhl jerseys wholesale nhl jerseys cheap nba jerseys cheap mlb jerseys wholesale mlb jerseys cheap nike jerseys cheap nike jerseys free shipping cheap authentic nfl nike jerseys nfl football jerseys china cheap authentic football jerseys replica football jerseys cheap football jerseys authentic cheap football jerseys paypal cheap nfl football jerseys wholesale football jerseys cheap china replica football jerseys china nfl jerseys supply cheap replica jerseys china replica football jerseys china cheap jerseys Wholesale Jerseys China wholesale authentic jerseys nfl jerseys from china cheap nfl jerseys china buy cheap nfl jerseys wholesale nfl jerseys china cheap nhl jerseys china wholesale nhl jerseys china cheap nba jerseys china wholesale nba jerseys china cheap mlb jerseys china wholesale mlb jerseys china nike jerseys china cheap nike jerseys with free shipping nfl nike jerseys wholesale cheap custom football jerseys replica nfl football jerseys cheap authentic football jerseys china football jerseys replica replica football jerseys cheap wholesale nfl jerseys supply replica nfl jerseys nike replica nfl jerseys cheap jerseys for sale Wholesale Jerseys From China wholesale sports jerseys nfl jerseys free shipping cheap nfl jerseys from china where to buy cheap nfl jerseys wholesale nfl jerseys from china cheap nhl jerseys from china wholesale nhl jerseys from china cheap mlb jerseys from china wholesale mlb jerseys from china nike jerseys free shipping cheap nike jerseys china discount nfl nike jerseys cheap custom football jerseys cheap football jerseys for sale wholesale football jerseys usa wholesale football jerseys china buy football jerseys from china football jerseys from china wholesale cheap jerseys supply cheap replica sports jerseys replica jerseys nfl wholesale cheap jerseys wholesale jerseys from china free shipping wholesale jerseys supply cheap nfl jerseys wholesale cheap nfl jerseys paypal wholesale nfl jerseys paypal cheap nhl jerseys wholesale nhl hockey jerseys wholesale cheap nba basketball jerseys wholesale basketball jerseys cheap mlb jerseys paypal wholesale mlb jerseys paypal wholesale nike jerseys paypal wholesale authentic nike jerseys wholesale nfl nike jerseys china custom college football jerseys where to buy football jerseys cheap youth replica football jerseys cheap football jerseys kids cheap football jerseys nike authentic football jerseys wholesale nike football jerseys wholesale cheap blank football jerseys cheap nfl jerseys supply replica jerseys china wholesale replica jerseys cheap replica nfl football jerseys cheap nfl jerseys free shipping where to get cheap nfl jerseys wholesale nhl jerseys free shipping cheap nba jerseys free shipping wholesale nba jerseys cheap cheap mlb jerseys free shippping wholesale mlb jerseys free shipping wholesale nike jerseys cheap nike jerseys wholesale nfl nike jerseys china custom youth football jerseys cheap wholesale football jerseys cheap football jerseys for women wholesale cheap football jerseys football jerseys cheap authentic nfl football jerseys china wholesale jerseys supply wholesale replica jerseys cheap replica throwback jerseys football replica jerseys cheap authentic jerseys Wholesale Nike NFL Jerseys nfl jerseys supply cheap nfl jerseys online cheap nfl nike jerseys wholesale nfl jerseys cheap cheap nhl jerseys online wholesale nhl jerseys paypal cheap stitched nba jerseys wholesale nba basketball jerseys wholesale mlb jerseys usa wholesale nike jerseys china cheap wholesale nfl nike jerseys wholesale nike football jerseys cheap throwback football jerseys wholesale kids football jerseys wholesale football jerseys suppliers authentic football jerseys for cheap wholesale ladies football jerseys cheap football jerseys with free shipping supply cheap jerseys reviews cheap youth replica jerseys nfl jerseys replica cheap nfl jerseys usa cheap nfl jerseys from china wholesale authentic nfl jerseys cheap nhl jerseys wholesale hockey jerseys cheap nba authentic jerseys authentic nba jerseys wholesale cheap mlb replica jerseys wholesale mlb baseball jerseys nike jerseys cheap jerseys china chinese nfl nike jerseys wholesale blank football jerseys cheap throwback football jerseys for sale cheap football jerseys stitched wholesale football jerseys youth wholesale nfl nike football jerseys womens football jerseys wholesale supply jerseys cheap kids replica jerseys replica sports jerseys wholesale cheap jerseys canada wholesale jerseys usa Wholesale Jerseys From China nfl jerseys china wholesale cheap nfl authentic jerseys cheap nfl jerseys wholesale wholesale nike nfl jerseys cheap nhl jerseys canada china wholesale nhl jerseys cheap retro nba jerseys buy cheap jerseys online nba cheap custom mlb jerseys wholesale baseball jerseys nike jerseys wholesale chinese wholesale nike jerseys cheap nfl nike jerseys china blank football jerseys wholesale wholesale nfl football jerseys wholesale nfl football jerseys from china wholesale football jerseys from china wholesale youth nfl football jerseys wholesale nike nfl football jerseys china football jerseys wholesale wholesale jerseys supply reviews wholesale jerseys replica wholesale nike jerseys paypal cheap nfl nike jerseys from china cheap youth practice football jerseys cheap wholesale jerseys discount nfl football jerseys wholesale nike elite football jerseys wholesale replica football jerseys cheap stitched football jerseys wholesale nfl jerseys supply review wholesale replica jerseys china cheap nfl replica jerseys replica nfl jerseys China Wholesale Jerseys wholesale authentic football jerseys cheap jerseys paypal cheap ncaa jerseys paypal cheap mlb jerseys paypal chinese wholesale jerseys nike football jerseys china cheap nike jerseys usa Wholesale Jerseys China nfl football jerseys discount cheap football jerseys online nfl jerseys cheap china replica nfl jerseys wholesale china nike jerseys cheap football jerseys cheap replica nfl jerseys nfl replica jerseys china wholesale jerseys usa cheap replica football jerseys replica nfl jerseys china Wholesale Jerseys From China football jerseys wholesale china youth football jerseys wholesale nfl jerseys china wholesale nike jerseys wholesale cheap china nfl nike jerseys cheap nfl authentic jerseys wholesale nhl hockey jerseys cheap nba jerseys for sale cheap nfl jerseys wholesale wholesale jerseys nhl cheap nba jerseys online wholesale nike nfl jerseys cheap wholesale nfl jerseys where to buy cheap nhl jerseys cheap nhl jerseys canada cheap stitched nfl jerseys cheap nike nfl jerseys china wholesale nhl jerseys buy wholesale jerseys nfl jerseys china cheap cheap retro nba jerseys cheap replica jerseys cheap wholesale jerseys from china buy cheap jerseys online nba cheap youth football jerseys cheap fake football jerseys cheap custom mlb jerseys nfl wholesale nike jerseys cheap custom football jerseys nike jerseys wholesale cheap nba jerseys wholesale cheap authentic nba jerseys cheap jerseys from china buy cheap jerseys from china cheap nike nfl jerseys cheap sports jerseys Wholesale Jerseys China buy wholesale jerseys wholesale authentic jerseys nfl jerseys from china cheap nfl jerseys china cheap nfl jerseys usa cheap nike nfl jerseys nfl jerseys from china nfl jerseys supply nfl jerseys cheap china authentic nfl jerseys wholesale custom nfl jerseys cheap customized nfl jerseys cheap china nfl jerseys cheap cheap official nfl jerseys super bowl jerseys nike super bowl jerseys buy super bowl jerseys wholesale super bowl XLIX jerseys super bowl 49 jerseys wholesale super bowl jerseys sale super bowl jerseys from china 2015 super bowl jerseys form china where to buy super bowl jerseys cheap nfl draft jerseys nfl super bowl jerseys nike super bowl jerseys super bowl 49 jerseys cheap super bowl jersey super bowl 49 jerseys wholesale nfl super bowl XLIX jerseys super bowl 49 jerseys patch 2015 super bowl jerseys form china nike nfl draft jerseys wholesale blank jerseys cheap blank football jerseys wholesale wholesale youth football practice jerseys cheap jerseys authentic reviews supply cheap jerseys reviews cheap stitched jerseys for kids wholesale replica jerseys china wholesale jerseys for women cheap jerseys online free shipping buy wholesale jerseys china nike jerseys cheap cheap sports jerseys and hats wholesale jerseys and hats cheap kids jerseys china cheap sports jerseys china wholesale jerseys china nike wholesale cheap jerseys usa cheap jerseys from china kids cheap jerseys wholesale usa cheap wholesale jerseys authentic super bowl jerseys nike super bowl jerseys buy super bowl jerseys cheap super bowl jerseys super bowl jerseys wholesale super bowl jerseys china cheap nfl super bowl jerseys fake super bowl jerseys where to buy super bowl jerseys cheap nfl draft jerseys cheap nfl jerseys cheap mlb jerseys cheap nfl jerseys paypal wholesale nfl jerseys cheap wholesale nfl jerseys cheap nhl jerseys online cheap hockey jerseys wholesale hockey jerseys cheap stitched nba jerseys cheap nba jerseys wholesale nba jerseys cheap mlb jerseys cheap nike jerseys nfl jerseys from china cheap nfl jerseys supply wholesale nike jerseys nfl jerseys china wholesale wholesale nfl jerseys cheap nhl jerseys cheap nhl jerseys cheap nba jerseys cheap nba jerseys cheap mlb jerseys replica sports jerseys cheap jerseys buy cheap jerseys china cheap jerseys cheap jerseys paypal Wholesale Jerseys wholesale jerseys usa wholesale sports jersey nfl jerseys china cheap nfl jerseys free shipping cheap nfl jerseys buy cheap nfl jerseys wholesale nfl jerseys wholesale authentic nfl jerseys cheap nhl jerseys cheap mlb jerseys wholesale cheap nfl jerseys cheap jerseys from china buy cheap jerseys china cheap jerseys cheap jerseys paypal Wholesale Jerseys wholesale jerseys usa wholesale nba jerseys from china cheap nhl jerseys canada football jerseys for cheap nike super bowl jerseys nhl jerseys china fake oakleys Balenciaga arena high louboutin replica chinese nhl jerseys fake oakley sunglasses Balenciaga black replica louboutin shoes wholesale nhl jerseys fake oakleys White balenciaga shoes replica louboutin wedges cheap nhl jerseys fake oakleys Balenciaga arena suede replica louboutin boots cheap nfl jerseys Balenciaga monochromes cheap red bottom shoes sale cheap super bowl jerseys replica oakley sunglasses balenciaga arena shoe in white replica louboutin shoes wholesale nba jerseys replica louboutin boots fake oakleys Christian louboutin sale nfl jerseys from china cheap louboutin heels fake oakleys Christian louboutin red bottoms wholesale jerseys china nike replica christian louboutin boots fake oakleys Shoes free shipping fake oakley sunglasses Balenciaga mens shoes cheap louboutin pumps cheap nfl nike jerseys fake oakley sunglasses Balenciaga arena sneakers replica louboutin heels cheap nba jerseys china fake oakley sunglasses Red balenciaga sneakers louboutin replica shoes wholesale nba jerseys from china fake oakley sunglasses Balenciaga arena lambskin low Sneakers louboutin replica pumps super bowl jersey shop fake oakley sunglasses stitched jerseys from china cheap red bottom shoes sale cheap oakley sunglasses Louboutin store cheap sports jerseys usa cheap red bottom shoes cheap oakley sunglasses Louboutin shop online cheap stitched nfl jerseys cheap louboutin boots fake oakley sunglasses Mens christian louboutin cheap custom nfl jerseys cheap replica louboutin shoes fake oakley sunglasses Cheap louboutins wholesale pro jerseys replica louboutin heels fake oakley sunglasses Louboutin boutique wholesale nfl jerseys nfl jerseys supply cheap louboutin outlet fake oakleys Christian louboutin mens shoes cheap nfl super bowl jerseys cheap louboutin heels cheap oakley sunglasses Discount louboutin shoes cheap wholesale jerseys authentic cheap louboutin shoes online discount oakley sunglasses giuseppe zanotti for men cheap jerseys from china authentic buy cheap red bottom shoes cheap oakley sunglasses men giuseppe zanotti shoes authentic nfl jerseys wholesale louboutin replica pumps fake oakleys sneakers giuseppe zanotti china nfl jerseys cheap cheap louboutin wedges fake oakleys men giuseppe sneakers cheap official nfl jerseys red bottom shoes for cheap cheap oakleys giuseppe zanotti for men replica oakley sunglasses cheap nike jerseys replica louboutin heels giuseppe zanotti shoe nhl jerseys china cheap louboutin pumps oakley sunglasses discount giuseppe zanotti high tops nfl jerseys from china cheap red bottom shoes sale oakley sunglasses discount shop designer shoes online chinese nhl jerseys cheap louboutin shoes online cheap oakleys giuseppe shoes men wholesale nhl jerseys china cheap louboutin outlet white maison martin margiela margiela high tops wholesale nike jerseys buy cheap nhl jerseys martin margiela sneaker super bowl jerseys china margiela e boutique cheap nfl jerseys louis vuitton mens sneakers cheap mlb jerseys Louis Vuitton trainers cheap jerseys gucci shoes Wholesale Jerseys gucci leather shoes cheap nhl jerseys wholesale soccer jerseys nfl jerseys supply cheap christian louboutin high heels men giuseppe zanotti
QUẢNG CÁO
 
Truy cập
Đang online: 1
Tổng số: 364,418
CHI TIẾT
Giám sát phản ứng có hại của thuốc ARV trên bệnh nhi tại một số cơ sở điều trị HIV/AIDS giai đoạn 2013 - 2016
Review on adverse drug reactions (ADRs) related to antiretroviral therapy (ART) in pediatric HIV/AIDS patients at some HIV/AIDS treatment bases Vietnam in 2013 – 2016
Vũ Đình Hòa, Nguyễn Phương Thúy, Đàm Thị Thanh Hương, Nguyễn Thị Phương Thịnh, Nguyễn Hoàng Anh b, Trần Ngân Hà, Phạm Lan Hương, Đỗ Thị Nhàn, Nguyễn Hoàng Anh
Số: 514 - Tháng 2/2019 - Trang 3-8

 Theo báo cáo tổng kết hoạt động của Cục Phòng, chống HIV/AIDS, tính đến tháng 6/2016, trên cả nước có khoảng 110.000 bệnh nhân được điều trị ARV, trong đó có 4865 bệnh nhân là trẻ em. Bệnh nhi nhiễm HIV/AIDS phần lớn là do lây truyền từ mẹ nên giai đoạn mang HIV không có triệu chứng thường ngắn, dễ tiến triển thành AIDS đầy đủ sau đó và tử vong sớm. Trong khi đó, việc điều trị ARV cho bệnh nhi hiện gặp nhiều khó khăn do các dạng thuốc được bào chế cho bệnh nhi còn hạn chế, xác định liều dùng phức tạp do bệnh nhi thay đổi cân nặng liên tục, việc tuân thủ điều trị phụ thuộc vào người chăm sóc, tỷ lệ bỏ điều trị cao đặc biệt ở trẻ vị thành niên và tỷ lệ trẻ chuyển sang phác đồ bậc 2 cao hơn so với người lớn. Những yếu tố này ảnh hưởng đến sự xuất hiện biến cố bất lợi, thất bại điều trị và tiềm ẩn nguy cơ kháng thuốc. Nghiên cứu này được thực hiện với mục tiêu xác định đặc điểm phản ứng có hại của thuốc ARV và các yếu tố ảnh hưởng đến sự xuất hiện phản ứng có hại (ADR) gây thay đổi phác đồ trên bệnh nhi điều trị HIV/AIDS tại một số cơ sở trọng điểm trong giai đoạn từ năm 2013 đến năm 2016.

Đối tượng

Bệnh án của bệnh nhi nhiễm HIV/AIDS ≤ 12 tuổi được bắt đầu điều trị bằng phác đồ có chứa thuốc ARV kể từ ngày 16/07/2013 đến hết ngày 15/03/2016 tại 8 phòng khám ngoại trú (PKNT) nhi điều trị HIV/AIDS.          Phương pháp nghiên cứu

Nghiên cứu mô tả, hồi cứu kết hợp tiến cứu theo dõi dọc bệnh nhi theo thời gian.

Dữ liệu về sử dụng thuốc, phản ứng có hại của phác đồ ARV và các thông tin khác của mỗi bệnh nhi được thu thập bằng các biểu mẫu nghiên cứu được thiết kế sẵn.

- Ghi nhận thông tin ban đầu

- Theo dõi biến cố bất lợi (ADE) trong các lần tái khám

- Thẩm định ADE và đánh giá mức độ nghiêm trọng

- ADR của thuốc ARV

Kết quả

            Nghiên cứu đã ghi nhận đặc điểm ADR của thuốc ARV gồm tần suất xuất hiện ADR (34,0 %) và tác động của ADR đến điều trị ARV. Trong đó, rối loạn hồng cầu - máu (16,0 %), rối loạn về da và mô dưới da (7,7 %), rối loạn hệ tiêu hóa (5,6 %) và rối loạn hệ gan - mật (5,0 %) là các phản ứng được ghi nhận nhiều nhất. ADR là nguyên nhân chính khiến bệnh nhi thay đổi phác đồ (67,7 %) chủ yếu liên quan đến thiếu máu, dị ứng trên da và rối loạn tiêu hóa. Bên cạnh đó, nghiên cứu đã xác định giai đoạn lâm sàng 4 là yếu tố nguy cơ làm tăng tần suất xuất hiện ADR gây đổi phác đồ (3,1 lần). Kết quả thu được cung cấp thông tin về ADR bệnh nhi gặp phải khi điều trị bằng của thuốc ARV từ đó tạo tiền đề cho những can thiệp mang tính chất hệ thống, góp phần nâng cao chất lượng điều trị cho đối tượng đặc biệt này.

 Adverse drug reactions (ADRs) related to antiretroviral therapy (ART) in pediatric HIV/AIDS patients at 8 sentinel sites were characterised. Related data of pediatric HIV/AIDS outpatients aged ≤ 12 were retrorespectively collected since ART initiation on 16/07/2013 and followed until 15th Sep 2016. Information related to AE from each site was sent to The National DI&ADR Center using paper-based forms. Total number of enrolled patients was 338 at the mean age of 57.1 ± 41.9 months. Male accounted for 52.1 %. AZT-based regimens were most frequently used (72.5 %) followed by AZT- based regimens (26.0 %) and TDF-based regimens (1.5 %). 115 patients experienced at least one ADR during treatment period (34.0 %). The most common ADRs were red blood cell disorder (16.0 %) followed by skin and appendages disorders (7.7 %). Treatment regimen switching occurred in 19.2 % patients, of these 67.7 % were due to ADRs. Multivariate Cox regression showed that clinical stage 4 was associated with higher red blood cell disorders (HR=3.9; 95 % CI: 1.7-8.9) and with higher risk of ADRs causing ART regimen alteration (HR=3.1; 95 % CI: 1.6 - 6.0). In conclusion, the incidence of ADRs from ART was high. The ADRs incidence and risk factors explored by this study would provide helpful information for appropriate treatment and intervention.
Quay trở lại

Bản quyền thuộc về Tạp chí Dược học – Bộ Y tế

Địa chỉ: 138 A Giảng Võ - Quận Ba Đình - Thành phố Hà Nội

Điện thoại: 04.37367717 – 04.37368367 - E-mail: tapchiduocbyt@gmail.com